Pathogen Repository

The Pathogen Repository is a part of the infrastructure "Bioresources, Biodata and Digital Health" (TI BBD) of the German Center for Infection Research (DZIF) and is located at the Leibniz Institute DSMZ. This infrastructure provides information on biosamples and collections of pathogens, databases, analysis tools or apps, as well as templates, samples or work instructions that are needed more than ever for translational infection research.  Currently, the Pathogen Repository comprises approximately 3,000 authenticated, clinically relevant microorganisms from >250 bacterial genera. This collection of isolates is increasing continuously. Tailored to the individual needs of DZIF researchers, various deposit options have been developed (public collection, closed collection with exclusive access, security deposit and backup storage), which are free of charge. In order to support the selection of relevant strains by the depositors, a novel key strain concept has been developed, which includes relevant selection criteria (e.g. new pathogens, reference strains, strains of multicenter studies, important outbreak strains, microbiome strains). Thus, an pathogen biobank adapted to the needs of the DZIF TTUs was established at the Leibniz Institute DSMZ, which ensures the availability of quality-controlled, standardized and well-documented microorganisms and the associated data.
For more details please visit our Pathogen Repository collection pages.

Selected references:

1. Zautner AE, Riedel T, Bunk B, Spröer C, Boahen KG, Akenten CW, Dreyer A, Färber J, Kaasch AJ, Overmann J, May J and Dekker D (2023) Molecular characterization of Arcobacter butzleri isolates from poultry in rural Ghana. Front Cell Infect Microbiol, 13:1094067.
2. Afrizal A, Jennings SAV, Hitch TCA, Riedel T, Basic M, Panyot A, Treichel N, Hager FT, Wong EO, Wolter B, Viehof A, von Strempel A, Eberl C, Buhl EM, Abt B, Bleich A, Tolba R, Blank LM, Navarre WW, Kiessling F, Horz HP, Torow N, Cerovic V, Stecher B, Strowig T, Overmann J, Clavel T. (2022) Enhanced cultured diversity of the mouse gut microbiota enables custom-made synthetic communities. Cell Host Microbe, 30:1630-1645.e25.
3. Afrizal A, Hitch TCA, Viehof A, Treichel N, Riedel T, Abt B, Buhl EM, Kohlheyer D, Overmann J, Clavel T. (2022) Anaerobic single-cell dispensing facilitates the cultivation of human gut bacteria. Environ Microbiol, 24:3861-3881.
4. Kopf A, Bunk B, Coldewey SM, Gunzer F, Riedel T, Schröttner P. (2022) Comparative Genomic Analysis of the Human Pathogen Wohlfahrtiimonas Chitiniclastica Provides Insight Into the Identification of Antimicrobial Resistance Genotypes and Potential Virulence Traits. Front Cell Infect Microbiol, 12:912427.
5. Zenner C, Hitch TCA, Riedel T, Wortmann E, Tiede S, Buhl EM, Abt B, Neuhaus K, Velge P, Overmann J, Kaspers B, Clavel T. (2021) Early-Life Immune System Maturation in Chickens Using a Synthetic Community of Cultured Gut Bacteria. mSystems, 6:e01300-20.